An invasive weed with close relatives among native species is a challenge for biological control. Houndstongue was introduced accidentally to North America from Eurasia in the mid-19th century. It has since invaded most Canadian provinces and adjacent US states. There are many native plants in the USA in the same family as houndstongue. CABI staff in Switzerland are investigating specialized natural enemies in the area of origin of the weed that could be introduced as biological control agents.